Medicinal qualities:

In vivo

Anticancer

Limonene-induced regression of mammary carcinomas.

Haag J.D., Lindstrom M.J., Gould M.N.

Read Abstract

Anti-inflammatory

Evaluation of Anti-Inflammatory Activity of Citrus latifolia Tanaka Essential Oil and Limonene in Experimental Mouse Models.

Kummer R., Fachini-Queiroz F.C., Estevão-Silva C.F., Grespan R., Silva E.L., Bersani-Amado C.A., Cuman R.K.

Read Abstract

Anti-anxiety & Sedative

Anti-stress effects of d-limonene and its metabolite perillyl alcohol.

d’Alessio P.A., Bisson J.F., Béné M.C.

Read Abstract

Anxiolytic and sedative effects of extracts and essential oil from Citrus aurantium L.

Carvalho-Freitas M.I., Costa M.

Read Abstract

Effects of the essential oil from Citrus aurantium L. in experimental anxiety models in mice.

A. de Moraes Pultrini, L.A. Galindo, M. Costa

Read Abstract

Central effects of citral, myrcene and limonene, constituents of essential oil chemotypes from Lippia alba (Mill.) N.E. Brown.

T. Gurgel do Vale, E. Couto Furtado, J.G. Santos Jr., G.S.B. Viana

Read Abstract

Antidepressant

Antihyperalgesic and antidepressive actions of (R)-(+)-limonene, α-phellandrene, and essential oil from Schinus terebinthifolius fruits in a neuropathic pain model.

Piccinelli A.C., Santos J.A., Konkiewitz E.C., Oesterreich S.A., Formagio A.S., Croda J., Ziff E.B., Kassuya C.A.

Read Abstract

Analgesic

Limonene reduces hyperalgesia induced by gp120 and cytokines by modulation of IL-1 β and protein expression in spinal cord of mice.

Piccinelli A.C., Morato P.N., Dos Santos Barbosa M., Croda J., Sampson J., Kong X., Konkiewitz E.C., Ziff E.B., Amaya-Farfan J., Kassuya C.A.

Read Abstract

Antioxidant

Protective effects of D-limonene on lipid peroxidation and antioxidant enzymes in streptozotocin-induced diabetic rats.

Murali R., Karthikeyan A., Saravanan R.

Read Abstract

Antioxidative and Cholesterol-Lowering Effects of Lemon Essential Oil in Hypercholesterolemia-Induced Rabbits.

Lee H., Woo M., Kim M., Noh J.S., Song Y.O.

Read Abstract

In vitro

Anticancer

Targeting apoptosis pathway with natural terpenoids: implications for treatment of breast and prostate cancer.

Yang H., Dou Q.P.

Read Abstract

Induction of apoptosis by D-limonene is mediated by inactivation of Akt in LS174T human colon cancer cells.

Jia S.S., Xi G.P., Zhang M., Chen Y.B., Lei B., Dong X.S., Yang Y.M.

Read Abstract

Anti-inflammatory

Limonene suppresses lipopolysaccharide-induced production of nitric oxide, prostaglandin E2, and pro-inflammatory cytokines in RAW 264.7 macrophages.

Yoon W.J., Lee N.H., Hyun C.G.

Read Abstract

Antioxidant

Protective Effect of D-Limonene against Oxidative Stress-Induced Cell Damage in Human Lens Epithelial Cells via the p38 Pathway.

Bai J., Zheng Y., Wang G., Liu P.

Read Abstract

The antioxidant and antigenotoxic properties of citrus phenolics limonene and naringin.

Bacanlı M., Başaran A.A., Başaran N.

Read Abstract

In vivo & in vitro

Anti-inflammatory

Skin repair properties of d-Limonene and perillyl alcohol in murine models.

d’Alessio P.A., Mirshahi M., Bisson J.F., Bene M.C.

Read Abstract

Gastrointestinal health

Oral administration of d-limonene controls inflammation in rat colitis and displays anti-inflammatory properties as diet supplementation in humans.

d’Alessio P.A., Ostan R., Bisson J.F., Schulzke J.D., Ursini M.V., Béné M.C.

Read Abstract

High D-Limonene strain-specific terpene formulations:

Skunk #1 Terpenes

View Details

One of the most famous strains, characterized by its dominant pungent skunky aroma

50ml
265$
250ml
1,062$

Super Lemon Haze Terpenes

View Details

A ‘Terpinolene’ dominant sativa strain with refreshing citrus aroma

50ml
343$
250ml
1,375$