FREE DOMESTIC AND INTERNATIONAL SHIPPING
×

Please join the Eybna Insiders Community

    Please refer to our Privacy Policy for more information 
    β-Caryophyllene chemical structure

    Medicinal qualities:

    In vivo

    Anti-anxiety

    β-Caryophyllene, a CB2 receptor agonist produces multiple behavioral changes relevant to anxiety and depression in mice.

    Bahi, A., Al Mansouri, S., Al Memari, E., Al Ameri, M., Nurulain, S. M., & Ojha, S. (2014)

    Read Abstract

    The anxiolytic-like effect of an essential oil derived from Spiranthera odoratissima A. St. Hil. leaves and its major component, β-caryophyllene, in male mice.

    Galdino, P. M., Nascimento, M. V., Florentino, I. F., Lino, R. C., Fajemiroye, J. O., Chaibub, B. A., de Paula, J. R., de Lima, T. C., & Costa, E. A. (2012)

    Read Abstract

    β-Caryophyllene, a CB2 receptor agonist produces multiple behavioral changes relevant to anxiety and depression in mice.

    Bahi A1, Al Mansouri S, Al Memari E, Al Ameri M, Nurulain SM, Ojha S.(2014)

    Read Abstract

    Anti-Cancer

    Beta caryophyllene and caryophyllene oxide, isolated from Aegle marmelos, as the potent anti-inflammatory agents against lymphoma and neuroblastoma cells.

    Sain S, Naoghare PK, Devi SS, Daiwile A, Krishnamurthi K, Arrigo P, Chakrabarti T(2014)

    Read Abstract

    β-Caryophyllene, a Compound Isolated from the Biblical Balm of Gilead (Commiphora gileadensis), Is a Selective Apoptosis Inducer for Tumor Cell Lines.

    Amiel E1, Ofir R, Dudai N, Soloway E, Rabinsky T, Rachmilevitch S.(2012)

    Read Abstract

    Antimicrobial activity of terpenoids from Copaifera langsdorffii Desf. against cariogenic bacteria.

    Souza AB, Martins CH, Souza MG, Furtado NA, Heleno VC, de Sousa JP, Rocha EM, Bastos JK, Cunha WR, Veneziani RC, Ambrósio SR.(2011)

    Read Abstract

    Potentiating effect of beta-caryophyllene on anticancer activity of alpha-humulene, isocaryophyllene and paclitaxel.

    Legault J1, Pichette A.(2007)

    Read Abstract

    β-caryophyllene and β-caryophyllene oxide-natural compounds of anticancer and analgesic properties.

    Fidyt K, Fiedorowicz A, Strządała L, Szumny A. (2016)

    Read Abstract

    Anti-inflammatory

    Investigation of the anti-inflammatory and analgesic activities of β-Caryophyllene.

    Bakır, B., Him, A., Özbek, H., Düz, E., & Tütüncü, M. (2008)

    Read Abstract

    β-Caryophyllene, the major constituent of copaiba oil, reduces systemic inflammation and oxidative stress in arthritic rats.

    Ames-Sibin, A. P., Barizão, C. L., Castro-Ghizoni, C. V., Silva, F. M. S., Sá-Nakanishi, A. B., Bracht, L., Bersani-Amado, C. A., & Marçal-Natali, M. R. (2018)

    Read Abstract

    Anti-inflammatory effects of compounds alpha-humulene and (-)-trans-caryophyllene isolated from the essential oil of Cordia verbenacea.

    Fernandes, E. S., Passos, G. F., Medeiros, R., da Cunha, F. M., Ferreira, J., Campos, M. M., Pianowski, L. F., & Calixto, J. B. (2007)

    Read Abstract

    Amelioration of dextran sulfate sodium-induced colitis in mice by oral administration of beta-caryophyllene, a sesquiterpene.

    Cho, J. Y., Chang, H. J., Lee, S. K., Kim, H. J., Hwang, J. K., & Chun, H. S. (2007)

    Read Abstract

    Anti-Inflammatory, Antioxidant, Antibiotic, and Cytotoxic Activities of Tanacetum vulgare L. Essential Oil and Its Constituents

    Héloïse Coté, Marie-Anne Boucher, André Pichette, and Jean Legault(2017)

    Read Abstract

    Prevent Alzheimer's Disease

    PPARgamma agonists as therapeutics for the treatment of Alzheimer’s disease.

    Landreth G1, Jiang Q, Mandrekar S, Heneka M.(2008)

    Read Abstract

    In vivo

    Prevent Diabetes

    β-Caryophyllene, a natural sesquiterpene, modulates carbohydrate metabolism in streptozotocin-induced diabetic rats.

    Basha RH, Sankaranarayanan C.(2014)

    Read Abstract

    Antinociception

    Involvement of peripheral cannabinoid and opioid receptors in β-caryophyllene-induced antinociception

    Katsuyama, S., Mizoguchi, H., Kuwahata, H., Komatsu, T., Nagaoka, K., Nakamura, H., Bagetta, G., Sakurada, T., & Sakurada, S. (2013)

    Read Abstract

    In vivo

    Increase Longevity And Mitochondrial Function

    Activation of type 2 cannabinoid receptors (CB2R) promotes fatty acid oxidation through the SIRT1/PGC-1α pathway.

    Zheng X, Sun T, Wang X. (2013)

    Read Abstract

    β-caryophyllene, a dietary cannabinoid, complexed with β-cyclodextrin produced anti-hyperalgesic effect involving the inhibition of Fos expression in superficial dorsal horn.

     

    Quintans-Júnior LJ1, Araújo AA, Brito RG, Santos PL, Quintans JS, Menezes PP2, Serafini MR, Silva GF, Carvalho FM, Brogden NK, Sluka KA. (2016)

     

    Read Abstract

    Local anaesthetic activity of beta-caryophyllene.

     

    Ghelardini C1, Galeotti N, Di Cesare Mannelli L, Mazzanti G, Bartolini A. (2001)

     

    Read Abstract

    In vivo

    Protects Kidney

    Amiel E1, Ofir R, Dudai N, Soloway E, Rabinsky T, Rachmilevitch S.β-Caryophyllene ameliorates cisplatin-induced nephrotoxicity in a cannabinoid 2 receptor-dependent manner.

    Horváth B1, Mukhopadhyay P, Kechrid M, Patel V, Tanchian G, Wink DA, Gertsch J, Pacher P.(2012)

    Read Abstract

    In vivo

    Relieves Pain

    Involvement of peripheral cannabinoid and opioid receptors in β-caryophyllene-induced antinociception.

    Katsuyama S, Mizoguchi H, Kuwahata H, Komatsu T, Nagaoka K, Nakamura H, Bagetta G, Sakurada T, Sakurada S.(2013)

    Read Abstract

    In vitro

    Antispasmodic - Ileum

    Antispasmodic effects of essential oil of Pterodon polygalaeflorus and its main constituent β-caryophyllene on rat isolated ileum.

    Leonhardt, V., Leal-Cardoso, J. H., Lahlou, S., Albuquerque, A. A., Porto, R. S., Celedônio, N. R., Oliveira, A. C., Pereira, R. F., Silva, L. P., Garcia-Teófilo, T. M., Silva, A. P., Magalhães, P. J., Duarte, G. P., & Coelho-de-Souza, A. N. (2010)

    Read Abstract

    Skin Repair

    Synergistic interaction of β-caryophyllene with aromadendrene oxide 2 and phytol induces apoptosis on skin epidermoid cancer cells.

    Pavithra PS, Mehta A, Verma RS. (2018)

    Read Abstract

    Skin Absorption

    Determination of β-caryophyllene skin permeation/retention from crude copaiba oil (Copaifera multijuga Hayne) and respective oil-based nanoemulsion using a novel HS-GC/MS method.

     

    Lucca LG, de Matos SP, Borille BT, de O Dias D, Teixeira HF, Veiga VF Jr, Limberger RP, Koester LS. (2015)

    Read Abstract

    High β-Caryophyllene strain-specific terpene formulations:

    OG kush terpene bottle

    The intense yet pleasant aroma makes this phenotype of the most popular in the world.

    50ml / 1.7oz$25800
    250ml / 8.4oz$1,07300
    Bubba kush Terpene bottle

    While it proves to be a challenge for cultivation, this phenotype is considered to be one of the fullest and most desired aromatic profiles on the planet.

    50ml / 1.7oz$20000
    250ml / 8.4oz$83200