Beta-Caryophyllene – Terpene Profile
Characterized by its spicy and peppery odor, this sesquiterpene is most commonly found in cloves, black pepper, basil, oregano and cannabis. Three isomers (α-, β-, and γ-caryophyllene) are found in nature where β-Caryophyllene is the most frequently encountered and most abundant. In addition, as an outstanding feature, β-Caryophyllene is suggested to bind with CB2 receptors and activate the endocannabinoid system.
β-Caryophyllene, a CB2 receptor agonist produces multiple behavioral changes relevant to anxiety and depression in mice.
The anxiolytic-like effect of an essential oil derived from Spiranthera odoratissima A. St. Hil. leaves and its major component, β-caryophyllene, in male mice.
Involvement of peripheral cannabinoid and opioid receptors in β-caryophyllene-induced antinociception
Investigation of the anti-inflammatory and analgesic activities of β-Caryophyllene.
β-Caryophyllene, the major constituent of copaiba oil, reduces systemic inflammation and oxidative stress in arthritic rats.
Anti-inflammatory effects of compounds alpha-humulene and (-)-trans-caryophyllene isolated from the essential oil of Cordia verbenacea.
Amelioration of dextran sulfate sodium-induced colitis in mice by oral administration of beta-caryophyllene, a sesquiterpene.
Antispasmodic - Ileum
Antispasmodic effects of essential oil of Pterodon polygalaeflorus and its main constituent β-caryophyllene on rat isolated ileum.