Medicinal qualities:

In vivo

Anti-anxiety

β-Caryophyllene, a CB2 receptor agonist produces multiple behavioral changes relevant to anxiety and depression in mice.

Bahi, A., Al Mansouri, S., Al Memari, E., Al Ameri, M., Nurulain, S. M., & Ojha, S. (2014)

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The anxiolytic-like effect of an essential oil derived from Spiranthera odoratissima A. St. Hil. leaves and its major component, β-caryophyllene, in male mice.

Galdino, P. M., Nascimento, M. V., Florentino, I. F., Lino, R. C., Fajemiroye, J. O., Chaibub, B. A., de Paula, J. R., de Lima, T. C., & Costa, E. A. (2012)

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Antinociception

Involvement of peripheral cannabinoid and opioid receptors in β-caryophyllene-induced antinociception

Katsuyama, S., Mizoguchi, H., Kuwahata, H., Komatsu, T., Nagaoka, K., Nakamura, H., Bagetta, G., Sakurada, T., & Sakurada, S. (2013)

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Anti-inflammatory

Investigation of the anti-inflammatory and analgesic activities of β-Caryophyllene.

Bakır, B., Him, A., Özbek, H., Düz, E., & Tütüncü, M. (2008)

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β-Caryophyllene, the major constituent of copaiba oil, reduces systemic inflammation and oxidative stress in arthritic rats.

Ames-Sibin, A. P., Barizão, C. L., Castro-Ghizoni, C. V., Silva, F. M. S., Sá-Nakanishi, A. B., Bracht, L., Bersani-Amado, C. A., & Marçal-Natali, M. R. (2018)

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Anti-inflammatory effects of compounds alpha-humulene and (-)-trans-caryophyllene isolated from the essential oil of Cordia verbenacea.

Fernandes, E. S., Passos, G. F., Medeiros, R., da Cunha, F. M., Ferreira, J., Campos, M. M., Pianowski, L. F., & Calixto, J. B. (2007)

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Amelioration of dextran sulfate sodium-induced colitis in mice by oral administration of beta-caryophyllene, a sesquiterpene.

Cho, J. Y., Chang, H. J., Lee, S. K., Kim, H. J., Hwang, J. K., & Chun, H. S. (2007)

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In vitro

Antispasmodic - Ileum

Antispasmodic effects of essential oil of Pterodon polygalaeflorus and its main constituent β-caryophyllene on rat isolated ileum.

Leonhardt, V., Leal-Cardoso, J. H., Lahlou, S., Albuquerque, A. A., Porto, R. S., Celedônio, N. R., Oliveira, A. C., Pereira, R. F., Silva, L. P., Garcia-Teófilo, T. M., Silva, A. P., Magalhães, P. J., Duarte, G. P., & Coelho-de-Souza, A. N. (2010)

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High β-Caryophyllene strain-specific terpene formulations:

 Characterized by its spicy and peppery odor, this sesquiterpene is most commonly found in cloves, black pepper, basil, oregano and cannabis. Three […]

50ml
362$
250ml
1,450$

 Characterized by its spicy and peppery odor, this sesquiterpene is most commonly found in cloves, black pepper, basil, oregano and cannabis. Three […]

50ml
281$
250ml
1,125$