Characterized by its spicy and peppery odor, this sesquiterpene is most commonly found in cloves, black pepper, basil, oregano and cannabis. Three isomers (α-, β-, and γ-caryophyllene) are found in nature where β-Caryophyllene is the most frequently encountered and most abundant. In addition, as an outstanding feature, β-Caryophyllene is suggested to bind with CB2 receptors and activate the endocannabinoid system.
β-Caryophyllene, a CB2 receptor agonist produces multiple behavioral changes relevant to anxiety and depression in mice.
Investigation of the anti-inflammatory and analgesic activities of β-Caryophyllene.